How it works
Your dog already makes GLP-1
It's a natural hormone, made by every mammal. G-Loop™ supports that essential signal every day, starting in the gut.*
Why it matters
Metabolic health shapes how dogs age
657more days
In Purina's Life Span Study, Labradors kept lean for life lived longer: 657 more days, at the median. Researchers tied the difference to the lean dogs' healthier metabolism.
12hallmarks of aging
Scientists group the biology of aging into 12 hallmarks. All 12 are closely connected to one another. Two of them, nutrient sensing and gut balance, tie directly to GLP-1.
Sources: Kealy et al., Journal of the American Veterinary Medical Association, 2002 (median life span 13.0 vs. 11.2 years); Larson et al., Journal of Nutrition, 2003; López-Otín et al., Cell, 2023; Holst, Physiological Reviews, 2007; Everard and Cani, Reviews in Endocrine & Metabolic Disorders, 2014.
What GLP-1 does
Three systems, one signal
GLP-1 carries one signal to three systems in your dog's body. Healthy aging is all three working in sync.*
Gut health
GLP-1 is made in your dog's gut lining, and a healthy gut makes more of it.*
Metabolic health
GLP-1 helps coordinate how your dog digests food and uses energy.*
Cellular health
GLP-1 signaling also reaches your dog's cells, day after day.*
Why we're confident
Studied in people. Built for dogs.
In people
The active ingredient in G-Loop™, ERIOMIN®, has been tested in three randomized, double-blind, placebo-controlled trials in adults. At 200 mg a day for 12 weeks, it raised GLP-1 levels in every one.
Change in GLP-1, 200 mg of ERIOMIN® a day for 12 weeks
The placebo groups showed little or no change. Tap a journal to read the study.
Why it carries over to dogs
Dogs have the same GLP-1 system. The same cells in the gut lining release it, and the same signals from gut bacteria tell them when.
These studies were in people. They’re why we built G-Loop™ for dogs, who share the same GLP-1 system.*
The loop
Your dog's gut does the work
ERIOMIN® is the fuel. Your dog’s gut bacteria do the work: they turn it into short-chain fatty acids, which tell the gut lining to release GLP-1. G-Loop™ doesn’t add GLP-1. It helps your dog’s body release its own.*
The prebiotics, probiotics, and postbiotics in every stick keep those bacteria strong. A healthier gut makes more of the signal, and the loop keeps going. That loop is where G-Loop™ gets its name.
ERIOMIN® and prebiotics
ERIOMIN® is the raw material, and prebiotics feed the gut bacteria that put it to work.
Gut bacteria
Gut bacteria, backed up by probiotics, turn ERIOMIN® into short-chain fatty acids.
Short-chain fatty acids
These messengers, called postbiotics, signal the gut lining and help hold it together.*
GLP-1
The gut lining releases GLP-1.* A healthier gut makes more of it, and the loop starts again.
The people
The scientists behind G-Loop™
Dr. Thais Cesar, PhD
Clinical nutrition researcher, São Paulo State University (UNESP)
A world leader in citrus flavonoid research, with more than 30 years of clinical work. She led the 2022 ERIOMIN® GLP-1 trial.
Read her study
Dr. Dragan Milenkovic, PhD
Associate professor, North Carolina State University
An expert in how plant compounds like flavonoids affect gut, heart, and metabolic health, with more than 100 peer-reviewed papers.
Dr. Bart Dunsford, PhD, PAS
Pet nutrition and product development
More than 25 years formulating pet nutrition, including probiotics, prebiotics, and postbiotics. He advises on G-Loop™'s formula.
Dr. Stephanie Lipp, DVM
Veterinarian, UC Davis graduate
Nearly 30 years in practice, focused on preventive care. She brings the clinic's view of what dogs need to thrive.
FAQ
Questions about the science
GLP-1 (glucagon-like peptide-1) is a natural hormone made in the gut, in dogs and in people. It helps coordinate metabolism, energy balance, and digestion.*
No. G-Loop™ is a daily supplement. It doesn't contain GLP-1 or synthetic GLP-1, and it isn't a GLP-1 agonist drug. It supports your dog's own GLP-1 activity, and it's powered by ERIOMIN®, a citrus bioflavonoid clinically tested in humans.
That's where the research on ERIOMIN® is today: three human trials, each showing higher GLP-1. Dogs share the same GLP-1 system, which is why we built G-Loop™ around it. We share the human results as our reason, not as dog results.
G-Loop™ is not a weight-loss supplement. It's formulated to support healthy weight management as part of daily care. No supplement makes up for extra treats, so your part still matters.
Whole citrus fruits (like lemons) can irritate dogs, but G-Loop™ uses purified citrus bioflavonoids, not oils or acids. It's formulated to complement your dog's biology and help keep everything in balance.